The year is 2200 AD. The world has taken quite a drastic turn, all thanks to a group of female biologists who would alter the world's history.
It began with a drug created in the middle 21st century which was purposely leaked into the water supply of the United States by this group of radical female biologists, an underground group called Fembiologica. They had discovered a compound which would affect the DNA of women, making them bigger, stronger, and smarter. They had kept it a secret, distributing it among themselves and producing it under the guise of other projects.
Around this time, they also discovered a separate compound which only affected the DNA of males, making them insatiably horny and willing to yield their desires and lives to the women entirely. The immense power of this drug was not lost on the women, and they began using it to gain key positions of power in the government and scientific communities. There was no one they could not seduce, no one who could not become corrupted with their plans. The women grew hungrier and hungrier, seeing the potential for complete world domination using these two drugs.
As time went on, the drug for the males, M64 evolved greatly, not only making the men insatiably horny but making them smaller, less intelligent, and physically weaker. The group of females obtained ownership slowly of all public water reservoirs and began slowly adding both drugs to the water, so little that it would be undetectable. The female drug, F99, also advanced tremendously, leading to smarter and smarter women who were living longer, aging less quickly, and becoming quite physically imposing.